The DigiBioMarC ™ (DBM) Kaiser app is designed as a low burden virtual tool to exquisitely capture key longitudinal biometric data from patients that may or may not be participating in clinical trials. This data can be used to rapidly discern troubling trends before they lead to symptom development and safety concerns that may cause poor care outcomes or trial drop out. Ultimately, data can be shared with clinical trial teams in real time so they are aware of possible safety and retention concerns and can act quickly to prevent poor outcomes that currently increase care, trial costs and undermine efficacy.